News

Dr. Fei serves as Conference Chair for the International Conference of SPIE Medical Imaging: Image-Guided Procedures, Robotic Interventions, and Modeling in 2017-2020.
SPIE is an international society advancing an interdisciplinary approach to the science and application of light. Established in 1955, the not-for-profit society advances emerging technologies through interdisciplinary information exchange, continuing education, publications, patent precedent, and career and professional growth. The SPIE Medical Imaging Conference is the internationally recognized premier forum for reporting state-of-the-art research and development in medical imaging. The event focuses on the latest innovations found in underlying fundamental scientific principles, to technology developments, scientific evaluation, and clinical application. In 2017, the conference will offer a special track on Precision Medicine. The symposium covers the full range of medical imaging modalities including medical image acquisition, display, processing, analysis, perception, decision support, and informatics. - April 2016

For more information, please visit the conference website:
https://spie.org/MI/conferencedetails/image-guided-procedures/

Call-for-Papers  


Dr. Baowei Fei served on the NIH Study Section ZRG1 SBIB-F (59)R on Imaging and Biomarker for Early Detection of Aggressive Cancer
The purpose of this Funding Opportunity Announcement (FOA) is to: (i) invite researchers to submit collaborative research project (U01) applications to improve cancer screening, early detection of aggressive cancer, assessment of cancer risk and cancer diagnosis aimed at integrating multi-modality imaging strategies and multiplexed biomarker methodologies into a singular complementary approach, and (ii) establish a Consortium for Imaging and Biomarkers (CIB) to perform collaborative studies, exchange information, share knowledge and leverage common resources. The research will be conducted by individual multi-disciplinary research teams, hereafter called Units. All Units are expected to participate in collaborative activities with other Units within the Consortium. - April 2017

For more information about this NIH program, please visit: https://grants.nih.gov/grants/guide/pa-files/PAR-16-089.html/

Dr. Baowei Fei served as Chair for NIH Study Section ZRG1 SBIB-F (56)R on Early Phase Clinical Trials in Imaging and Image-guided Interventions
This Funding Opportunity Announcement (FOA) is intended to support clinical trials conducting preliminary evaluation of the safety and efficacy of imaging agents, as well as an assessment of imaging systems, image processing, image-guided therapy, contrast kinetic modeling, 3-D reconstruction and other quantitative tools. As many such preliminary evaluations are early in development, this FOA will provide investigators with support for pilot (Phase I and II) cancer imaging clinical trials, including patient monitoring and laboratory studies. This FOA supports novel uses of known/standard clinical imaging agents and methods as well as the evaluation of new agents, systems, or methods. The imaging and image-guided intervention (IGI) investigations, if proven successful in these early clinical trials, can then be validated in larger studies through competitive R01 mechanisms, or through clinical trials in the Specialized Programs of Research Excellence (SPOREs), Cancer Centers and/or the NCI's National Clinical Trials Network. - February 2017

For more information about this NIH program, please visit: https://grants.nih.gov/grants/guide/pa-files/PAR-14-166.html/

Dr. Baowei Fei Organized the Workshop and Launch of the Integrative Cancer Imaging Research Program (iCIRP)
The Integrative Cancer Imaging Research Program (iCIRP) is a joint program between Emory University School of Medicine Department of Radiology and Imaging Sciences, Georgia Tech/Emory Coulter Department of Biomedical Engineering, and Winship Cancer Institute of Emory University. This program will build on and synergize unique strengths inherent in Emory units and centers that foster multidisciplinary collaborations within and among the disciplines of imaging science, cancer biology, nanotechnology, biomarker development, computation, and clinical cancer research. The overarching goal of the iCIRP program is to advance cancer detection, diagnosis, prognosis, image-guided therapy, prediction of efficacy, and monitoring of treatment. - October 28, 2016

For more information about this program, please visit: http://radiology.emory.edu/research/icirp/index.html/

For more information about the speakers, please read the Program  

Guolan Lu successfully defended her PhD thesis
As an emerging optical modality, hyperspectral imaging (HSI) holds great promise for early cancer detection and image-guided surgery. The major advantage of HSI is that it is a noninvasive technology that doesn't require any contrast agent, and it combines wide-field imaging and spectroscopy to simultaneously attain both spatial and spectral information from an object in a non-contact way. Light delivered to the tissue surface undergoes multiple elastic scattering and absorption interactions, and part of it returns as diffuse reflectance carrying diagnostic information about the underlying tissue structure and composition. The biochemical and morphological properties of the tissue change during disease progression. Therefore hyperspectral images, which contain high-dimensional spectral information at each image point, can be analyzed for visualization, characterization, and quantification of the disease state in biological tissue. The overall goal of this dissertation was to investigate the potential of label-free HSI technology combined with machine learning methods as a noninvasive diagnostic tool for quantitative detection and delineation of head and neck cancer. . - October 14, 2016

Guolan Lu Received the Outstanding Translational Research Award
This Outstanding Translational Research Award honors a graduate student who has demonstrated excellence in translational research as shown by publications in translation-focused journals, patents, clinical testing, achieving FDA clearance, etc. Guolan Lu received the 2016 Wallace B Coulter Department of Biomedical Engineering Annual Graduate Student Award – Outstanding Translational Research Award. Guolan is a Ph.D. candidate in the Quantitative BioImaging Laboratory and has performed her thesis research under the supervision of Prof. Baowei Fei in the Department of Radiology and Imaging at Emory University and in the Department of Biomedical Engineering at Emory University and Georgia Institute of Technology. Guolan’s research work on hyperspectral imaging demonstrated highly translational potential from animals to human patients for the applications in cancer detection and image-guided surgery. One of her papers on medical hyperspectral imaging has received national and international attentions, being cited more than 200 times in only two years and being the Top Download from Journal of Biomedical Optics. This prestigious award is to honor best and brightest among more than 150 Ph.D. students in the nationally top-ranked Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology. - May 2, 2016

For more information about this Award, please visit: http://www.gradadmiss.gatech.edu/hg/item/531711/

Top Downloads from Journal of Biomedical Optics: http://biomedicaloptics.spiedigitallibrary.org/journal.aspx/

Lu G and Fei B, "Medical hyperspectral imaging: a review", Journal of Biomedical Optics. 19(1), 010901 (Jan 20, 2014) http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1816617/

FDA approves Emory-developed prostate cancer imaging probe (FACBC/Axumin)
A cancer imaging agent that was originally developed at Emory University was approved on Friday, May 27 by the U.S. Food and Drug Administration. Axumin, a PET (positron emission tomography) imaging agent, is indicated for diagnosis of recurrent prostate cancer in men who have elevated blood levels of prostate specific antigen (PSA) after previous treatment. Axumin, now being commercialized by UK-based Blue Earth Diagnostics, is also known as 18F-fluciclovine or FACBC (an abbreviation for anti-1-amino-3-[18F]fluorocyclobutane-1- carboxylic acid). Imaging using axumin is expected to help doctors detect and localize recurrent prostate cancer, and could guide biopsy or the planning of additional treatment, says David Schuster, MD, director of the Division of Nuclear Medicine and Molecular Imaging and associate professor of radiology and imaging sciences at Emory University School of Medicine and Winship Cancer Institute. Fluciclovine was originally developed by Mark Goodman, PhD, professor of radiology and imaging sciences at Emory University School of Medicine and Winship Cancer Institute, and Emory Endowed Chair of Imaging Sciences, along with Timothy Shoup, PhD, now at Massachusetts General Hospital. Baowei Fei, PhD, EngD, is researching how to combine fluciclovine with ultrasound to guide prostate biopsy. Fei is associate professor of radiology and imaging sciences, a Georgia Research Alliance Distinguished Cancer Scientist, and part of the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory. - June 2016

For more information about this news, please visit: http://news.emory.edu/stories/2016/06/fluciclovine_fda_approval/

For more information about the targeted biopsy study, please visit: https://www.clinicaltrials.gov/ct2/show/NCT02744534/

Dr. Baowei Fei and Dr. Xulei Qin at QBIL were granted a U.S. patent on cardiac imaging
Systems, methods, and computer-readable storage media relate to segmenting an image series of at least one image of a region of interest of a subject. The methods, systems, and computer readable storage media can automatically segment interior and exterior boundaries relative to the region of interest (e.g., epicardial and endocardial boundaries with respect to a right ventricle) from an image series by combining sparse matrix transform, a training model, and a localized region based level set function. - April 2016

Fei B, Qin X, “Systems, methods and computer readable storage media storing instructions for automatically segmenting images of a region of interest”, United States Patent , No. 9,142,030 B2 Full Text

Ms. Guolan Lu, PhD Candidate at QBIL, won the Outstanding Translational Research Award at Georgia Tech
This Outstanding Translational Research Award honors a graduate student who has demonstrated excellence in translational research as demonstrated by publications in translation-focused journals, patents, clinical testing, achieving FDA clearance, etc. Guolan's research work on hyperspectral imaging demonstrated highly translational potential from animals and human patients for cancer detection and image-guided surgery. This is a prestigious award among more than 150 PhD students in the top-ranked Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology. - April 2016

Lu G, Fei B, “Medical Hyperspectral Imaging: A Review”, Journal of Biomedical Optics, Jan. 2014, 10901 Full Text

Dr. Zhiqiang Tian at QBIL won the Second Place for the MICCAI PROMISE12 Challenge
The MICCAI 'Prostate MR Image Segmentation Challenge (PROMISE12) is to compare interactive and (semi)-automatic segmentation algorithms for MRI of the prostate. The results of the challenge were presented in conjunction with a live challenge, evaluating the algorithms on unseen data. Eighteen teams (research groups, companies, etc.) who are developing a segmentation algorithm registered and downloaded multi-center, multi-vendor training data from the PROMISE12 website to train their algorithms. Test data were also be supplied. The segmentation results of the algorithms on the test data were submitted through the website, including a short paper explaining the algorithm. The segmentations were automatically evaluated against the reference standard. The results of the algorithms were then ranked and shown in the results section of the website. Among the 18 research teams from the international community, the QBIL team from Emory University won the second place for this MICCAI PROMISE12 Challenge.- July 2015

For more information about the MICCAI PROMISE12 Challenge, please visit: http://promise12.grand-challenge.org/Results/Overview

Dr. Baowei Fei received a grant from Children's Healthcare of Atlanta Research Centers
The project is to investigate cardiac fiber orientation and is supported by the Children's Healthcare of Atlanta Research Centers - Center for Cardiovascular Biology. (Co-Pls: Baowei Fei and Mary Wagner. - July 2014

For more information about the Children's Healthcare of Atlanta, please visit: http://www.choa.org

Dr. Baowei Fei was invited to give the C. Dayton Riddle Distinguished Lecture at Clemson University
Dr. Fei was invited to give this distinguished lecture on multimodality imaging and image-guided intervention in the Department of Bioengineering at Clemson University. This lecture was jointly supported by CUBEInC and Clemson University Biomedical Engineering Innovation Programs. - March 2014

For more information about Clemson University, please visit: http://www.clemson.edu

Dr. Baowei Fei was named as a Distinguished Investigator by the Academy of Radiology Research
The award is to recognize individuals for their accomplishments in imaging research. The program is intended to especially encourage those who have achieved scientific excellence while still being involved in clinical care, but it is not limited to clinician scientists only. Recipients of this award will become a member of the Council of Distinguished Investigators of the Academy of Radiology Research. The Academy of Radiology Research is an alliance of 28 professional imaging societies. Established in 1995, the Academy was the catalyst for creating the National Institute of Biomedical Imaging and Bioengineering (NIBIB), for supporting its growth and development, for accelerating investment in vital imaging research areas by other NIH institutes, and for building support for radiology and imaging in Congress and the Executive Branch. The Academy is the umbrella organization to the Coalition for Imaging and Bioengineering Research (CIBR) and the Academic Council (ARRAC).- June 2013

For more information about Academy of Radiology Research, please visit: http://www.acadrad.org

Dr. Baowei Fei was invited to serve in an AAPM Technology Assessment Committee - Work Group on Image-Guided Interventions
The American Association of Physicists in Medicine (AAPM) is a scientific, educational, and professional organization of medical physicists. The AAPM promotes the application of physics to medicine and biology, encourage interest and training in medical physics and related fields. The AAPM has convened a task group on robotic-assisted interventions, which is coordinated by the Cancer Imaging Program of the National Cancer Institute (NCI) of the National Institute of Health (NIH).- April 2013

Dr. Baowei Fei was granted another U.S. patent for detecting cardiovascular diseases
A method is provided that comprises receiving a first digital radiography (DR) image of at least a portion of a body of a patient, receiving a second DR image of the at least a portion of a body of a patient, the first DR image being captured at a different energy level than the second DR image, and determining common control point locations for both the first and second DR images. The method further comprises generating an optimized DR image by moving portions of a selected one of the first and second DR images with its associated control points to locations that correspond to similar portions of the other of the first and second DR images, applying deformable transformation to one of the first and second DR images and performing a log subtraction on the first and second DR image to generate a dual-energy digital radiography (DEDR) image. - April 2013

Fei B, Gilkeson R, “Systems and methods for generating images for identifying diseases”, United States Patent , No. 8,422,757 Full Text

Dr. Baowei Fei's research on prostate biopsy is featured by the cover of Diagnostic Imaging Europe
In the January issue of Diagnostic Imaging Europe (DI Europe), the QBIL paper entitled “PET directed, 3D ultrasound-guided prostate biopsy” made the cover of the magazine that is published by DI Europe Ltd., an independent European-based publishing house. DI Europe is distributed to approximately 17 000 readers throughout Europe, which is published eight times a year and covers all the main imaging topics and sub-specialties. The readers are all clinicians or medical professionals in the radiology/medical imaging field. - Jan. 2013

Fei B, Nieh PT, Schuster DM, Master VA, “PET directed, 3D ultrasound-guided prostate biopsy”, Diagnostic Imaging Europe, Pages: 12-15, 2013 Full Text

To read the January issue of Diagnostic Imaging Europe, please visit: http://www.dieurope.com/feature-articles/diagnostic-imaging-articles/pet-directed-3d-ultrasoundguided-prostate-biopsy/index.html

QBIL's research work made the cover of Medical Physics
In the June issue of Medical Physics, the QBIL paper entitled “3D ultrasound image segmentation using wavelet support vector machines” made the cover of the journal. Medical Physics is an official science journal of the American Association of Physicists in Medicine. - June 2012

Akbari H, Fei BW (corresponding author). 3D ultrasound image segmentation using wavelet support vector machines, Medical Physics 2012;39:2972-2984. Full Text

To read the June issue of Medical Physics, please visit: http://online.medphys.org/resource/1/mphya6/v39/i6

Dr. Baowei Fei was invited to the NIH Biomedical Imaging Technology (BMIT) Study Section.
Dr. Fei was invited to the NIH Biomedical Imaging Technology (BMIT) Study Section. The BMIT Study Section reviews grant applications involving basic, applied, and pre-clinical aspects of the design and development of medical imaging system technologies, their components, software, and mathematical methods for studies at the cellular, organ, small or large animal, and human scale.
- Feb. 2012

Dr. Baowei Fei was granted a U.S. patent for detecting cardiovascular diseases
Systems and methods for generating images for identifying diseases are provided. In one embodiment, a method comprises receiving a first digital radiography (DR) image of at least a portion of a body of a patient, receiving a second DR image of the at least a portion of a body of a patient, the first DR image being captured at a different energy level than the second DR image, and determining common control point locations for both the first and second DR images. The method further comprises generating an optimized DR image by moving portions of a selected one of the first and second DR images with its associated control points to locations that correspond to similar portions of the other of the first and second DR images, applying deformable transformation to one of the first and second DR images and performing a log subtraction on the first and second DR image to generate a dual-energy digital radiography (DEDR) image. - Dec. 2011

Fei B, Gilkeson R, “Systems and methods for generating images for identifying diseases”, United States Patent , No. 8,073,230 Full Text

QBIL's research Work received the Cum Laude Poster Award at the 2011 SPIE Medical Imaging Conference.
Prostate image segmentation research received the Cum Laude Poster Award at the SPIE Medical Imaging: Visualization, Image-guided Procedures and Modeling Conference in Orlando, Florida on February 14, 2011. The research work was entitled "Automatic 3D segmentation of ultrasound images using atlas registration and statistical texture prior". Authors contributed to this work include X. Yang, D. Schuster, V. Master, P. Nieh, A. Fenster and B. Fei at Emory University. - February 2011

Dr. Baowei Fei received an Award for a Developmental Research Project from the Emory SPORE in Head and Neck Cancer.
Emory University Winship Cancer Institute (Emory WCI) Head and Neck Cancer Specialized Program of Research Excellence (SPORE) is funded by the NIH/NCI. The overall goal of the Emory WCI HNC SPORE is to improve prevention and treatment of head and neck cancer with emphasis on new discoveries, rapid translation to patients who are suffering, disability and morbidity caused by the disease. In this Developmental Research Project, Dr. Fei will collaborate with Drs. Georgia Chen, Dong Shin, and Ronald Voll and develop molecular imaging technology and photodynamic therapy for treatment of head and neck cancer in animal models. - February 2011

For more information about the Emory SPORE in Head and Neck, please visit: http://winshipcancer.emory.edu/SPORE-ed/index.htm

Congratulations to Andrew Chi for being admitted to the 2015 Class of the Medical College of Georgia.
On February 4, 2011, Andrew Chi received the admission letter to the 2015 Class from the Medical College of Georgia at Georgia Health Sciences University. Andrew is scheduled to graduate from Emory College in May of 2011 with a Bachelor's of Science in Chemistry and Bachelor's of Arts in East Asian Studies. - February 2011

Dr. Baowei Fei received a five-year NIH R01 grant on molecular image-directed, 3D ultrasound image guided biopsy.
Prostate cancer affects 1 in 6 men in the USA. Every man over the age of 45 is at risk for prostate cancer. Systematic transrectal ultrasound (TRUS)-guided biopsy is the standard method for a definitive diagnosis of prostate cancer. More than 1.2 million prostate biopsies are performed annually and the medical cost is more than two billion dollars each year. However, this technique has a significant sampling error and is characterized by low sensitivity (39-52%). The current biopsy approach can miss up to 30% of prostate cancers. As a negative biopsy does not preclude the possibility of a missed cancer, both the physicians and patients face challenges in making treatment decisions. Due to the increasing number of younger men with potentially early and curable prostate cancer, this problem must be addressed in order to improve cancer detection rate. This project is to develop a molecular image-directed, 3D ultrasound-guided system for targeted biopsy of the prostate. If completely developed, the multimodality molecular image-guided system will be able to be used not only for biopsy but also for brachytherapy, radiofrequency thermal ablation, cryotherapy, and photodynamic therapy. The research could improve prostate cancer detection by using novel molecular imaging technology and by using a new three-dimensional image-guided biopsy device. The molecular image-guided system can be used not only for improved biopsy of diseases but also for minimally invasive therapy of cancers. - January 2011

Dr. Baowei Fei's research is highlighted by Emory Magazine
Double Vision - By Mary J. Loftus
"The combined system can provide opportunities for basic research and can open a new window to studying diseases such as Alzheimer's, Parkinson's, drug addiction, cancer, and cardiovascular disease," says Assistant Professor of Radiology Baowei Fei, a Georgia Cancer Coalition Distinguished Scholar. Dr. Fei's team is working to develop and improve imaging software for the hybrid system. - Autumn 2010

For more information, please visit: http://www.emory.edu/EMORY_MAGAZINE/2010/autumn/scanner.html

Dr. Baowei Fei's work on MR/PET is highlighted as a featured innovation at the Office of Technology Transfer (OTT) at Emory University
Magnetic resonance imaging (MR) shows details about the soft tissues of the body, such as every curve and indentation in the brain, while positron emission tomography (PET) records processes, such as how much energy is being used or how much blood is flowing into a region. When these imaging techniques were combined in the same scanner a few years ago, a real challenge since the MRI's strong magnetic field and the PET's detector and electronics tend to interfere with each other scientists started thinking about the potential wealth of information that could be provided.

For more information, please visit:
When Two is Better Than One: Perfecting the Combined MR/PET

Dr. Baowei Fei's work on photodynamic therapy and nanoparticle-based drug delivery was highlighted by Nature Materials
Photodynamic therapy (PDT) is a promising method for treating several cancers that uses photosensitizers. The photosensitizer accumulates in target tissue and is excited using light, generating reactive oxygen species that induce cell death. To enter the target area PDT drugs need to be lipophilic, however this presents problems: lack of solubility in the physiological conditions experienced en route to the target means that they usually take at least 24 hours to get to the tumour. Baowei Fei, Clemens Burda and co-workers have synthesized a PDT drug complex that significantly decreases the delivery time and enables quantitative monitoring of the process. Polyethylene glycol (PEG; a compound approved for human intravenous applications) is attached to gold nanoparticles functionalized with the PDT drug, silicon phthalocyanine-4. Chains of PEG wrap around the drug allowing the system to disperse in aqueous conditions. Free silicon phthalocyanine-4 takes 1-2 days to accumulate in a tumour site; using the new complex this is reduced to less than two hours in vivo in cancer-bearing mice with the tumour reducing in size within one week of treatment.

For more information, please visit:
http://www.nature.com/nmat/journal/v7/n9/full/nmat2268.html

Dr. Baowei Fei received a Coulter Translational Research Award to develop quantification tools for combined MR/PET
PET (Positron Emission Tomography) provides insight into the metabolic and functional alterations related to pathologic process, and CT (Computed X-Ray Tomography) and MRI (Magnetic Resonance Imaging) reveal anatomical changes due to diseases. The combination of two imaging modalities significantly expands their utility, improving sensitivity and specificity for disease detection and diagnosis. With this grant from the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University Dr. Fei and his team will develop image quantification tools that include image registration, classification, segmentation, and attenuation correction for potential use in combined MR/PET. - July 2010

Dr. Baowei Fei received a Young Investigator Award from the Society of Nuclear Medicine (SNM)
At the 57th Annual Meeting of the Society of Nuclear Medicine (SNM) in Salt Lake City, Utah in June 2010, Dr. Baowei Fei received the Young Investigator Award for his research on Image Quantification and Attenuation Correction for Combined MRI/PET from the SNM. Dr. Fei received the 1st place award from the SNM Computer and Instrumentation Council. He and his co-colleagues have developed tools for image registration, classification, segmentation and attenuation correction for the potential use in combined MRI/PET. Other colleagues who contributed to this work include Mr. X. Yang, Dr. J. Nye, Ms. M. Jones, Dr. J. Aarsvold, Ms. N. Raghunath, Dr. C. Meltzer and Dr. J. Votaw. – June 2010.

Dr. Baowei Fei received a Pilot grant from the NIH-funded Emory Molecular and Translational Imaging Center
We envision that molecular imaging can detect cancer at the cellular level, can monitor drug distribution in vivo, can guide therapy to the target, and can evaluate efficacy immediately after therapy. Dr. Fei and his team will develop and evaluate multimodality imaging methods (fluorescence imaging, PET and MR imaging) for early detection of therapeutic response in pre-clinical cancer models. - September 2009.

Dr. Baowei Fei was selected as a Georgia Cancer Coalition Distinguished Cancer Scholar
The Georgia Cancer Coalition established the Distinguished Cancer Clinicians and Scientists program as the cornerstone of its research agenda. The goal of the program is to recruit to Georgia leading and nationally renowned cancer clinicians and scientists who are engaged in the most promising areas of cancer research. The selection of the scholars is closely aligned with the National Cancer Institute's "Extraordinary Opportunities in Cancer Research," which has identified areas of discovery that hold promise for making significant progress against all cancers. This competitive and prestigious award carries with it a five-year grant payable to Emory University to support Dr. Fei's research on cancer imaging. - June 15, 2009

For more information about Georgia Cancer Coalition, please visit: http://www.georgiacancer.org

Dr. Baowei Fei received a URC grant to fund his research project entitled "Motion Correction and Quantitative Image Analysis for Kidney MR Imaging."
The project is supported by the NIH sponsored Atlanta Clinical and Translational Institute (A-CTSI). (Co-Pls:Baowei Fei and Diego Martin. Co-investigator: John Votaw) - May 12, 2009

For more information about the Atlanta Clinical and Translational Institute, please visit: http://www.atlantactsi.org

For more information about the University Research Committee (URC), please visit: http://www.urc.emory.edu